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Role of sodium in mitochondrial membrane depolarization induced by P2X 7 receptor activation in submandibular glands
Author(s) -
Garcia-Marcos M.,
Fontanils U.,
Aguirre A.,
Pochet S.,
Dehaye J.P.,
Marino A.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.08.074
Subject(s) - depolarization , extracellular , biophysics , chemistry , sodium , receptor , membrane potential , mitochondrion , membrane , submandibular gland , biochemistry , microbiology and biotechnology , biology , endocrinology , organic chemistry
It is concluded that the activation of P2X 7 receptors depolarizes the mitochondrial membrane. The uptake of extracellular sodium is necessary but not sufficient to induce this response.