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Compositional variation in bacterial genes and proteins with potential expression level
Author(s) -
Das Sabyasachi,
Ghosh Subhagata,
Pan Archana,
Dutta Chitra
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.08.042
Subject(s) - gene , cytosine , expressivity , codon usage bias , bacteria , gc content , guanine , genetics , biology , chemistry , biochemistry , genome , nucleotide
Usage of guanine and cytosine at three codon sites in eubacterial genes vary distinctly with potential expressivity, as predicted by Codon Adaptation Index (CAI). In bacteria with moderate/high GC‐content, G 3 follows a biphasic relationship, while C 3 increases with CAI. In AT‐rich bacteria, correlation of CAI is negative with G 3 , but non‐specific with C 3 . Correlations of CAI with residues encoded by G‐starting codons are positive, while with those by C‐starting codons are usually negative/random. Average Size/Complexity Score and aromaticity of gene‐products decrease with CAI, confirming general validity of cost‐minimization principle in free‐living eubacteria. Alcoholicity of bacterial gene‐products usually decreases with expressivity.