Premium
p38 MAPK is involved in CB 2 receptor‐induced apoptosis of human leukaemia cells
Author(s) -
Herrera Blanca,
Carracedo Arkaitz,
Diez-Zaera María,
Guzmán Manuel,
Velasco Guillermo
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.08.021
Subject(s) - apoptosis , mapk/erk pathway , microbiology and biotechnology , p38 mitogen activated protein kinases , chemistry , receptor , cancer research , biology , signal transduction , biochemistry
Cannabinoids have been shown to inhibit the growth of a broad spectrum of tumour cells. However, the molecular mechanisms involved in that effect have not been completely elucidated. Here, we investigated the possible involvement of mitogen‐activated protein kinases (MAPKs) in CB 2 receptor‐induced apoptosis of human leukaemia cells. Results show that stimulation of the CB 2 receptor leads to p38 MAPK activation and that inhibition of this kinase attenuates CB 2 receptor‐induced caspase activation and apoptosis. These findings support a role for p38 MAPK in CB 2 receptor‐induced apoptosis of human leukaemia cells.