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RNA silencing in fungi: Mechanisms and applications
Author(s) -
Nakayashiki Hitoshi
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.08.016
Subject(s) - argonaute , dicer , rna induced silencing complex , rna silencing , gene silencing , biology , trans acting sirna , rna , neurospora crassa , rna induced transcriptional silencing , rna interference , genetics , neurospora , small interfering rna , microbiology and biotechnology , gene , mutant
Two RNA silencing‐related phenomena, quelling and meiotic silencing by unpaired DNA (MSUD) have been identified in the fungus Neurospora crassa . Similar to the case with the siRNA and miRNA pathways in Drosophila , different sets of protein components including RNA‐dependent RNA polymerase, argonaute and dicer, are used in the quelling and MSUD pathways. Orthologs of the RNA silencing components are found in most, but not all, fungal genomes currently available in the public databases, indicating that the majority of fungi possess the silencing machinery. Advantage and disadvantage of RNA silencing as a tool to explore gene function in fungi are discussed.