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RNAi mechanisms in Caenorhabditis elegans
Author(s) -
Grishok Alla
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.08.001
Subject(s) - rna interference , caenorhabditis elegans , gene silencing , rna silencing , biology , small interfering rna , gene , microbiology and biotechnology , genetics , rna
RNA interference (RNAi) is a form of gene silencing induced by double stranded RNA (dsRNA) that is processed into short interfering RNAs (siRNAs). RNAi can induce both post‐transcriptional and transcriptional gene silencing. In Caenorhabditis elegans , there are several distinct pathways where post‐transcriptional or/and transcriptional RNAi mechanisms are involved. RNAi in C. elegans is also systemic and heritable. This review will discuss RNAi related pathways, features of RNAi in C. elegans and possibilities of endogenous gene regulation by RNAi.