Premium
A novel 4.1 ezrin radixin moesin (FERM)‐containing protein, ‘Willin’
Author(s) -
Gunn-Moore Frank J.,
Welsh Gavin I.,
Herron Lissa R.,
Brannigan Frances,
Venkateswarlu Kanamarlapudi,
Gillespie Stewart,
Brandwein-Gensler Margaret,
Madan Rashna,
Tavaré Jeremy M.,
Brophy Peter J.,
Prystowsky Michael B.,
Guild Simon
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.07.097
Subject(s) - radixin , moesin , ezrin , chemistry , microbiology and biotechnology , ferm domain , biophysics , biochemistry , cytoskeleton , membrane protein , biology , membrane , cell , integral membrane protein
The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain‐containing protein called Willin. Willin has a recognizable FERM domain within its N‐terminus and is capable of binding phospholipids. Its intra‐cellular distribution can be cytoplasmic or at the plasma membrane where it can co‐localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.