Molecular recognition of nucleic acids: Coralyne binds strongly to poly(A) | Zendy

Xing Feifei | Zendy; Song Guangtao | Zendy; Ren Jinsong | Zendy; Chaires Jonathan B. | Zendy; Qu Xiaogang | Zendy

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Molecular recognition of nucleic acids: Coralyne binds strongly to poly(A)

Author(s) -

Xing Feifei,

Song Guangtao,

Ren Jinsong,

Chaires Jonathan B.,

Qu Xiaogang

Publication year - 2005

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2005.07.091

Subject(s) - nucleic acid , chemistry , molecular recognition , biochemistry , biophysics , stereochemistry , biology , organic chemistry , molecule

The small molecule coralyne was found to bind preferentially and strongly to single‐stranded poly(A) with an apparent association constant ( K a ) of (1.8 ± 0.3) × 10 6 M −1 . Binding of coralyne to poly(A) is predominantly enthalpically driven with a stoichiometry of one coralyne per four adenine bases. Poly(A) forms a coralyne dependent secondary structure with a melting temperature of 60 °C, for the conditions of our study.

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