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Mammalian mitochondria contain a soluble acyl carrier protein
Author(s) -
Cronan John E.,
Fearnley Ian M.,
Walker John E.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.07.077
Subject(s) - biochemistry , mitochondrion , acyl carrier protein , protein subunit , fatty acid synthesis , fatty acid , mitochondrial matrix , enzyme , biology , inner mitochondrial membrane , chemistry , biosynthesis , cytosol , gene
Plant and fungal mitochondria contain type II fatty acid synthesis systems closely related to those of bacteria in which the individual reactions are catalyzed by separate soluble proteins acting on intermediates bound to acyl carrier protein (ACP). Mammalian mitochondria are thought to synthesize fatty acids, but evidence for the key ACP component was lacking since the only reported ACP was the SDAP subunit of the membrane‐bound NADH:ubiquinone oxidoreductase, We report that most of the SDAP is found in the soluble (matrix) fraction of bovine heart mitochondria and is therefore available to carry the intermediates of type II fatty acid synthesis.