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Structural domains in RNAi
Author(s) -
Collins Robert E.,
Cheng Xiaodong
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.07.072
Subject(s) - drosha , dicer , rna interference , rna induced silencing complex , computational biology , gene silencing , rna silencing , microbiology and biotechnology , function (biology) , rna , argonaute , ribonuclease iii , biology , genetics , gene
Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double‐stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two related functions, highlighting models of Drosha, Dicer, and RISC function.