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The upstream area of the chicken α‐globin gene domain is transcribed in both directions in the same cells
Author(s) -
Borunova Victoria,
Iarovaia Olga V.,
Vassetzky Yegor S.,
Razin Sergey V.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.07.051
Subject(s) - gene , globin , biology , rna , dna , microbiology and biotechnology , genetics , messenger rna , gene expression
It was demonstrated previously that in erythroid chicken cells an extended upstream area of the α‐globin gene domain is transcribed in both directions as a part of ggPRX gene and a part of a full domain transcript of the α‐globin gene domain. Here, we show that both DNA chains of the above‐mentioned region are transcribed in the same cells and that the corresponding transcripts coexist in nuclei. The data obtained suggest that cells possess a molecular mechanism which in some cases prevents the formation of dsRNA and subsequent destruction of both transcripts in spite of the presence of complementary RNA chains in the cell nucleus.