Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting | Zendy

Coppola Anna | Zendy; Hughes Jeniter | Zendy; Esposito Emanuela | Zendy; Schiavo Luigi | Zendy; Meli Rosaria | Zendy; Diano Sabrina | Zendy

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Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting

Author(s) -

Coppola Anna,

Hughes Jeniter,

Esposito Emanuela,

Schiavo Luigi,

Meli Rosaria,

Diano Sabrina

Publication year - 2005

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2005.07.035

Subject(s) - medicine , endocrinology , deiodinase , hypothalamus , hormone , dio2 , thyroid , iodothyronine deiodinase , chemistry , thyroid hormones , messenger rna , thyrotropin releasing hormone , biology , gene , biochemistry

Fasting is characterized by disrupted thyroid feedback, with suppressed levels of thyroid hormones and paraventricular thyrotropin releasing hormone (TRH). We found that third ventricle administration of the deiodinase inhibitor, iopanoic acid, dose‐dependently reduced deiodinase type II (DII) activity selectively in the hypothalamus. This suppression of DII by iopanoic acid during fasting prevented elevated DII activity and blunted the decline in hypothalamic TRH mRNA levels. Because fasting‐induced elevation in hypothalamic DII activity is paralleled by increased hypothalamic T3 concentration, our study suggests that T3 formation by DII in the hypothalamus is the cause of disrupted thyroid feedback during fasting.

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