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Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis
Author(s) -
Ware Carol B.,
Kariagina Anastasia,
Zonis Svetlana,
Alon Dana,
Chesnokova Vera
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.07.014
Subject(s) - leukemia inhibitory factor receptor , leukemia inhibitory factor , medicine , endocrinology , receptor , signal transduction , messenger rna , chemistry , transcription factor , pituitary gland , biology , interleukin 6 , microbiology and biotechnology , hormone , cytokine , gene , biochemistry
Leukemia inhibitory factor (LIF) is expressed in the hypothalamic‐pituitary adrenal (HPA) axis and stimulates pituitary POMC transcription. The role of LIF receptor signaling in HPA axis development was examined. Lifr −/− and Lifr +/+ fetuses were obtained by Cesarean section on E18.5. Despite a 3‐fold induction of hypothalamic CRH mRNA, pituitary POMC mRNA and RU486‐induced ACTH levels were decreased in Lifr −/− mice. High CRH may be caused by increased central TNFα and IL‐6 expression. Lifr −/− mice demonstrate elevated pituitary glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA and protein levels, indicating the importance of LIF signaling for HPA axis development.