Regulation of uncoupling protein activity in phosphorylating potato tuber mitochondria | Zendy

Navet Rachel | Zendy; Douette Pierre | Zendy; Puttine-Marique Florence | Zendy; Sluse-Goffart Claudine M. | Zendy; Jarmuszkiewicz Wieslawa | Zendy; Sluse Francis E. | Zendy

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Regulation of uncoupling protein activity in phosphorylating potato tuber mitochondria

Author(s) -

Navet Rachel,

Douette Pierre,

Puttine-Marique Florence,

Sluse-Goffart Claudine M.,

Jarmuszkiewicz Wieslawa,

Sluse Francis E.

Publication year - 2005

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2005.07.008

Subject(s) - respiration , mitochondrion , antimycin a , phosphorylation , uncoupling agents , gtp' , chemistry , biochemistry , malonate , biology , botany , enzyme

In isolated potato tuber mitochondria, palmitic acid (PA) can induce a H + leak inhibited by GTP in the phosphorylating (state 3) respiration but not in the resting (state 4) respiration. The PA‐induced H + leak is constant when state 3 respiration is decreased by an inhibition of the succinate uptake with n ‐butyl malonate ( n BM). We show that the efficiency of inhibition by GTP is decreased when state 3 respiration is progressively inhibited by antimycin A (AA) and is restored following subsequent addition of n BM. We propose that in phosphorylating potato tuber mitochondria, the redox state of ubiquinone, which can antagonistically be varied with AA and n BM, modulates inhibition of the PA‐activated UCP‐sustained H + leak by GTP.

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