Premium
Raver2, a new member of the hnRNP family
Author(s) -
Kleinhenz Berenike,
Fabienke Manuela,
Swiniarski Sascha,
Wittenmayer Nina,
Kirsch Joachim,
Jockusch Brigitte M.,
Arnold Hans Henning,
Illenberger Susanne
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.07.001
Subject(s) - polypyrimidine tract binding protein , biology , nuclear export signal , nuclear localization sequence , microbiology and biotechnology , nuclear protein , rna , nucleus , rna binding protein , homology (biology) , cell nucleus , genetics , gene , transcription factor
Raver2 was identified as a novel member of the hnRNP family based on sequence homology within three RNA recognition motifs and its general domain organization reminiscent of the previously described raver1 protein. Like raver1, raver2 contains two putative nuclear localization signals and a potential nuclear export sequence, and also displays nucleo‐cytoplasmic shuttling in a heterokaryon assay. In glia cells and neurons, raver2 localizes to the nucleus. Moreover, the protein interacts with polypyrimidine tract binding protein (PTB) suggesting that it may participate in PTB‐mediated nuclear functions. In contrast to ubiquitously expressed raver1, raver2 exerts a distinct spatio‐temporal expression pattern during embryogenesis and is essentially restricted to brain, lung, and kidney in the adult mouse.