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Yeast HAT1 and HAT2 deletions have different life‐span and transcriptome phenotypes
Author(s) -
Rosaleny Lorena E.,
Antúnez Oreto,
Ruiz-García Ana B.,
Pérez-Ortín José E.,
Tordera Vicente
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.06.028
Subject(s) - mutant , transcriptome , biology , genetics , phenotype , histone acetyltransferase , acetyltransferase , histone , gene , gene expression , acetylation
HAT‐B is a yeast histone acetyltransferase composed of Hat1, Hat2 and Hif1 proteins. We demonstrate that a hat2 mutant or a hat1hat2 double mutant, but not a hat1 mutant, have an extended life‐span. Transcriptome analysis shows that the single hat mutants are not very different from wild type. However, the comparison of the hat1 and hat2 transcriptomes shows that they are different. The hat1hat2 double mutant shows a transcriptional phenotype similar to that of the hat1 mutant but strongly enhanced. These results indicate that Hat2p could have additional functions in the cell to those of Hat1p.