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Micromolar HgCl 2 concentrations transitorily duplicate the ATP level in Saccharomyces cerevisiae cells
Author(s) -
Silles Eduardo,
Osorio Hugo,
Maia Rita,
Günther Sillero María A.,
Sillero Antonio
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.06.017
Subject(s) - chemistry , saccharomyces cerevisiae , hexose , phosphofructokinase , hexokinase , atpase , biochemistry , glycolysis , inosine , metabolism , enzyme , yeast
Low concentrations of HgCl 2 elicited, in Saccharomyces cerevisiae , a transitory increase in the ATP level followed by a decrease of its concentration, until almost disappearance. At 1 μM HgCl 2 , the increase in ATP lasted for about 30 min, while at 10 μM the increase was only observed in the first 5 min of treatment. The initial burst of ATP was accompanied by a decrease in the level of hexose phosphates, whereas during the decrease of ATP an increase in the inosine and hexose phosphates levels took place. The treatment with HgCl 2 inhibited the plasma membrane proton ATPase but not the activities of hexokinase or 6‐phosphofructokinase.