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Involvement of circadian clock gene Clock in diabetes‐induced circadian augmentation of plasminogen activator inhibitor‐1 ( PAI‐1 ) expression in the mouse heart
Author(s) -
Oishi Katsutaka,
Ohkura Naoki,
Amagai Noriko,
Ishida Norio
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.05.027
Subject(s) - circadian rhythm , medicine , endocrinology , clock , circadian clock , diabetes mellitus , plasminogen activator inhibitor 1 , biology , streptozotocin , activator (genetics) , plasminogen activator , receptor
Diabetes is associated with an excess risk of cardiac events, and one of the risk factors for infarction is the elevated‐levels of plasminogen activator inhibitor‐1 (PAI‐1). To evaluate how the molecular clock mechanism is involved in the diabetes‐induced circadian augmentation of PAI‐1 gene expression, we examined the expression profiles of PAI‐1 mRNA in the hearts of Clock mutant mice with streptozotocin‐induced diabetes. Circadian expression of PAI‐1 mRNA was blunted to low levels under both normal and diabetic conditions in Clock mutant mice, although the expression rhythm was augmented in diabetic wild‐type (WT) mice. Furthermore, plasma PAI‐1 levels became significantly higher in WT mice than in Clock mutant mice after STZ administration. Our results suggested that the circadian clock component, CLOCK, is involved in the diabetes‐induced circadian augmentation of PAI‐1 expression in the mouse heart.