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Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus
Author(s) -
Samuelsen Ørjan,
Haukland Hanne H.,
Jenssen Håvard,
Krämer Manuela,
Sandvik Kjersti,
Ulvatne Hilde,
Vorland Lars H.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.05.017
Subject(s) - staphylococcus aureus , magainin , antimicrobial , cathelicidin , microbiology and biotechnology , peptide , antimicrobial peptides , antibiotic resistance , penicillin , cross resistance , chemistry , biology , bacteria , antibiotics , biochemistry , genetics
This study was designed to investigate inducible intrinsic resistance against lactoferricin B in Staphylococcus aureus . Serial passage of seven S. aureus strains in medium with increasing concentrations of peptide resulted in an induced resistance at various levels in all strains. The induced resistance was unstable and decreased relatively rapidly during passages in peptide free medium but the minimum inhibitory concentration remained elevated after thirty passages. Cross‐resistance to penicillin G and low‐level cross‐resistance to the antimicrobial peptides indolicidin and Ala 3,13,18 ‐magainin was observed. No cross‐resistance was observed to the human cathelicidin LL‐37. In conclusion, this study shows that S. aureus has intrinsic resistance mechanisms against antimicrobial peptides that can be induced upon exposure, and that this may confer low‐level cross‐resistance to other antimicrobial peptides.