A putative novel alpha/beta hydrolase ORFan family in  Bacillus | Zendy

Siew Naomi | Zendy; Saini Harpreet Kaur | Zendy; Fischer Daniel | Zendy

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A putative novel alpha/beta hydrolase ORFan family in Bacillus

Author(s) -

Siew Naomi,

Saini Harpreet Kaur,

Fischer Daniel

Publication year - 2005

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2005.04.030

Subject(s) - beta (programming language) , hydrolase , alpha (finance) , chemistry , microbiology and biotechnology , biochemistry , enzyme , biology , medicine , computer science , construct validity , nursing , patient satisfaction , programming language

A large number of sequences in each newly sequenced genome correspond to lineage and species‐specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold‐recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belong.

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