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Linear motifs: Evolutionary interaction switches
Author(s) -
Neduva Victor,
Russell Robert B.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.04.005
Subject(s) - affinities , computational biology , evolutionary biology , sequence (biology) , binding affinities , biology , sequence motif , function (biology) , genetics , receptor , biochemistry , dna
Linear motifs are short sequence patterns associated with a particular function. They differ fundamentally from longer, globular protein domains in terms of their binding affinities, evolution and in how they are found experimentally or computationally. In this Minireview, we discuss various aspects of these critically important functional regions.