Premium
Immune cell‐induced synthesis of NO and reactive oxygen species in lymphoma cells causes their death by apoptosis
Author(s) -
Hu De-En,
Brindle Kevin M.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.03.099
Subject(s) - reactive oxygen species , apoptosis , immune system , programmed cell death , chemistry , nitric oxide , microbiology and biotechnology , lymphoma , etoposide , cell culture , cancer research , biology , biochemistry , immunology , chemotherapy , genetics , organic chemistry
Induction of apoptosis in a lymphoma cell line using immune cell‐conditioned medium, etoposide or an nitric oxide (NO) donor, resulted in the production of reactive oxygen species (ROS). Agents that inhibited NO production or scavenged ROS or species formed by reaction of NO with ROS, protected the cells from apoptosis. These data support the suggestion that immune rejection of an immunogenic derivative of this lymphoma in vivo involves the induced synthesis of both NO and ROS by the tumour cells.