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Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: A pilot study
Author(s) -
Straface Elisabetta,
Matarrese Paola,
Gambardella Lucrezia,
Vona Rosa,
Sgadari Antonio,
Silveri Maria Caterina,
Malorni Walter
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.03.094
Subject(s) - oxidative stress , cystatin c , cathepsin d , medicine , peripheral blood , peripheral , oxidative phosphorylation , disease , endocrinology , antioxidant , alzheimer's disease , biology , biochemistry , creatinine , enzyme
Markers of oxidative stress in peripheral blood from patients with Alzheimer disease (AD) were analyzed. Thirty‐three AD patients were recruited. Plasma antioxidant power (AOP), plasma Cystatin C as well as Cathepsin D in PBL were evaluated. We found that the AOP levels were significantly decreased in AD patients if compared to healthy donors, while the plasma level of Cystatin C was significantly higher. Importantly, a significantly decreased expression of Cathepsin D in PBL was also observed. These results suggest that oxidative imbalance in the peripheral blood of AD patients could mirror oxidative changes previously described in the central nervous system.