Premium
Molecular characterization of the first satellite DNA with CENP‐B and CDEIII motifs in the bat Pipistrellus kuhli
Author(s) -
Fantaccione Stefania,
Pontecorvo Giovanni,
Zampella Vincenzo
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.03.064
Subject(s) - centromere , satellite dna , biology , dna , genetics , dna sequencing , meiosis , mitosis , microbiology and biotechnology , chromosome , gene
The centromere is an essential structure in the chromosomes of all eukariotes and is central to the mechanism that ensures proper segregation during mitosis and meiosis. The comparison of DNA sequence motifs, organization and kinetocore components from yeast to man is beginning to indicate that, although centromeres are highly variable DNA elements, a conserved pattern of sequence arrangement and function is emerging. We have identified and characterized the first satellite DNA ( P.k. SAT) from microbat species Pipistrellus kuhli . The presence of mammalian CENP‐B box and yeast CDEIII box could indicate the participation of P.k. SAT in centromere organization.