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Histamine elevates the expression of Ets‐1, a protooncogen in human melanoma cell lines through H2 receptor
Author(s) -
Hegyesi Hargita,
Horváth Barnabás,
Pállinger Éva,
Pós Zoltán,
Molnár Viktor,
Falus András
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.03.053
Subject(s) - histamine , receptor , histamine h2 receptor , melanoma , histamine receptor , cell culture , chemistry , microbiology and biotechnology , cancer research , medicine , pharmacology , biology , biochemistry , genetics , antagonist
Histamine is known to act, at least in part, as a growth factor for several cell types, and as production of this biogen amine has been found to accelerate the rate of tissue proliferation in wound repair, embryogenesis and malignant growth. Abundant experimental and clinical data suggest that histamine augments in vivo tumour cell proliferation via histamine H2 receptors (H2R). Here, we report that exogenously added histamine stimulates Ets‐1 (v‐ets erythroblastosis virus E26 oncogene homolog 1) synthesis in human melanoma cells. Involvement of histamine receptors in the histamine induced ets‐1 expression has been also studied. Our data show that these newly recognized actions of histamine are mediated by the H2R. Modification of local protooncogen Ets‐1 level is likely being involved in the regulation of melanoma growth.