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Dosage compensation in flies: Mechanism, models, mystery
Author(s) -
Straub Tobias,
Dahlsveen Ina K.,
Becker Peter B.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.03.050
Subject(s) - dosage compensation , mechanism (biology) , compensation (psychology) , context (archaeology) , biology , gene dosage , genetics , computational biology , drosophila (subgenus) , transcription (linguistics) , chromosome , evolutionary biology , gene , gene expression , physics , psychology , paleontology , linguistics , philosophy , quantum mechanics , psychoanalysis
Dosage compensation involves fine‐tuning of gene expression at the level of entire chromosomes. The principles that assure selective targeting of the male X chromosome in Drosophila and the mechanism by which transcription levels are adjusted in a twofold range are still mysterious. We discuss the prevalent models in the context of recent experimental observations.