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Oncogenic breakdowns in endocytic adaptor proteins
Author(s) -
Crosetto Nicola,
Tikkanen Ritva,
Dikic Ivan
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.03.029
Subject(s) - endocytic cycle , endocytosis , signal transducing adaptor protein , microbiology and biotechnology , function (biology) , effector , endosome , biology , receptor , signal transduction , biochemistry , intracellular
Endocytosis is a versatile tool to regulate the intensity, localization, half‐life and function of signaling complexes (signalosomes) that form in cells upon binding of growth factors, cytokines and morphogens to their cognate receptors. Endocytic adaptors are non‐catalytic proteins that assemble effectors and structural components of the endocytic machinery around the trafficking cargo and serve as scaffolds for signalosomes, which in turn modify their location and activity by various post‐translational modifications. We discuss how breakdowns in the function of endocytic adaptors might facilitate impairment of tissue homeostasis and consequent tumor development.