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Assembly of hereditary amyloid β‐protein variants in the presence of favorable gangliosides
Author(s) -
Yamamoto Naoki,
Hirabayashi Yoshio,
Amari Masakuni,
Yamaguchi Haruyasu,
Romanov Galina,
Van Nostrand William E.,
Yanagisawa Katsuhiko
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.03.013
Subject(s) - ganglioside , basement membrane , amyloid (mycology) , flemish , downregulation and upregulation , chemistry , microbiology and biotechnology , biology , biochemistry , gene , inorganic chemistry , history , archaeology
The mechanisms underlying regional amyloid β‐protein (Aβ) deposition in brain remain unclear. Here we show that assembly of hereditary variant Dutch‐ and Italian‐type Aβs, and Flemish‐type Aβ was accelerated by GM3 ganglioside, and GD3 ganglioside, respectively. Notably, cerebrovascular smooth muscle cells, which compose the cerebral vessel wall at which the Dutch‐ and Italian‐type Aβs deposit, exclusively express GM3 whereas GD3 is upregulated in the co‐culture of endothelial cells and astrocytes, which forms the cerebrovascular basement membrane, the site of Flemish‐type Aβ deposition. Our results suggest that regional Aβ deposition is induced by the local gangliosides in the brain.