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Na v 1.6 channels generate resurgent sodium currents in spinal sensory neurons
Author(s) -
Cummins Theodore R.,
Dib-Hajj Sulayman D.,
Herzog Raimund I.,
Waxman Stephen G.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.03.009
Subject(s) - dorsal root ganglion , sodium channel , sensory system , neuroscience , biophysics , sensory neuron , sodium , neuron , chemistry , dorsum , nav1 , anatomy , physics , biology , organic chemistry
The Na v 1.6 voltage‐gated sodium channel has been implicated in the generation of resurgent currents in cerebellar Purkinje neurons. Our data show that resurgent sodium currents are produced by some large diameter dorsal root ganglion (DRG) neurons from wild‐type mice, but not from Na v 1.6‐null mice; small DRG neurons do not produce resurgent currents. Many, but not all, DRG neurons transfected with Na v 1.6 produce resurgent currents. These results demonstrate for the first time the intrinsic ability of Na v 1.6 to produce a resurgent current, and also show that cell background is critical in permitting the generation of these currents.