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Polarised distribution of the RNA‐binding protein Staufen in differentiated intestinal epithelial cells
Author(s) -
Gautrey Hannah,
McConnell Josie,
Hall Judith,
Hesketh John
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.02.074
Subject(s) - rna binding protein , microbiology and biotechnology , messenger rna , rna , rna processing , distribution (mathematics) , biology , chemistry , gene , genetics , mathematical analysis , mathematics
mRNA localisation, as a mechanism for directing localised protein synthesis, plays a vital role in the functioning of certain cells, such as neurons and oocytes. Potentially this mechanism may also occur in polarised intestinal epithelial cells. Here we show that Staufen1 55 , a protein involved in mRNA localisation and transport, is asymmetrically distributed in differentiated Caco‐2 intestinal epithelial cells and partly co‐localised with calnexin, a marker of the endoplasmic reticulum. The localisation to the apical region of the cell indicates that Staufen may be involved in localisation of transcripts to this domain.