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Psychophysiological stress‐regulated gene expression in mice
Author(s) -
Murata Shigenori,
Yoshiara Taeko,
Lim Chun Ren,
Sugino Maiko,
Kogure Mitori,
Ohnuki Tatsuya,
Komurasaki Toshi,
Matsubara Kenichi
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.02.069
Subject(s) - gene , gene expression , biology , transcription (linguistics) , microbiology and biotechnology , genetics , philosophy , linguistics
Eight genes showed significant changes in expression in mice under psychophysiological stress provided by cage‐restraint and water‐immersion. The transcription level of most of these genes was affected in all the tissues analyzed, and some of them were responsive genes in several different stress systems. Peculiarly, the expression level of one gene, cdc2‐like kinase 1 (CLK1), was reduced only in the brain, while the balance of partially‐ and alternatively‐spliced CLK1 mRNA species changed in all the tissues including the brain. These results suggest that some stress‐response mechanisms, including transcriptional and post‐transcriptional events, are coordinated in the whole body in mice under psychophysiological stress.