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Functional role of AMP‐activated protein kinase in the heart during exercise
Author(s) -
Musi Nicolas,
Hirshman Michael F.,
Arad Michael,
Xing Yanqiu,
Fujii Nobuharu,
Pomerleau Jason,
Ahmad Ferhaan,
Berul Charles I.,
Seidman Jon G.,
Tian Rong,
Goodyear Laurie J.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.02.052
Subject(s) - ampk , medicine , protein kinase a , glycogen , cardiac function curve , endocrinology , genetically modified mouse , homeostasis , amp activated protein kinase , phosphorylation , cardiology , chemistry , heart failure , transgene , biochemistry , gene
AMP‐activated protein kinase (AMPK) plays a critical role in maintaining energy homeostasis and cardiac function during ischemia in the heart. However, the functional role of AMPK in the heart during exercise is unknown. We examined whether acute exercise increases AMPK activity in mouse hearts and determined the significance of these increases by studying transgenic (TG) mice expressing a cardiac‐specific dominant‐negative (inactivating) AMPKα2 subunit. Exercise increased cardiac AMPKα2 activity in the wild type mice but not in TG. We found that inactivation of AMPK did not result in abnormal ATP and glycogen consumption during exercise, cardiac function assessed by heart rhythm telemetry and stress echocardiography, or in maximal exercise capacity.