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Cold exposure differently influences mitochondrial energy efficiency in rat liver and skeletal muscle
Author(s) -
Mollica Maria Pina,
Lionetti Lillà,
Crescenzo Raffaella,
Tasso Rosaria,
Barletta Antonio,
Liverini Giovanna,
Iossa Susanna
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.02.044
Subject(s) - skeletal muscle , oxidative phosphorylation , mitochondrion , uncoupling protein , medicine , endocrinology , biology , chemistry , biochemistry , brown adipose tissue , adipose tissue
This study deals with mitochondrial energy efficiency in liver and skeletal muscle mitochondria in 15 days cold exposed rats. Cold exposure strongly increases the sensitivity to uncoupling by added palmitate of skeletal muscle but not liver mitochondria, while mitochondrial energy coupling in the absence of fatty acids is only slightly affected by cold in liver and skeletal muscle. In addition, uncoupling protein 3 content does not follow changes in skeletal muscle mitochondrial coupling. It is therefore concluded that skeletal muscle could play a direct thermogenic role based on fatty acid‐induced mild uncoupling of mitochondrial oxidative phosphorylation.