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Structure‐based systems biology: a zoom lens for the cell
Author(s) -
Aloy Patrick,
Russell Robert B
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.02.014
Subject(s) - zoom , systems biology , zoom lens , key (lock) , computational biology , structural biology , computer science , connection (principal bundle) , biology , cell , complex system , nanotechnology , lens (geology) , microbiology and biotechnology , artificial intelligence , materials science , genetics , engineering , ecology , paleontology , structural engineering
Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types of information. Here, we discuss how the incorporation of high‐resolution structural data can provide key molecular details often necessary to understand the complex connection between individual molecules and cell behavior. We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the interfaces of interacting proteins.