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When kinases meet mathematics: the systems biology of MAPK signalling
Author(s) -
Kolch Walter,
Calder Muffy,
Gilbert David
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.02.002
Subject(s) - crosstalk , mapk/erk pathway , kinase , microbiology and biotechnology , signalling , motility , systems biology , biology , signal transduction , scaffold protein , signalling pathways , function (biology) , computational biology , physics , optics
The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified and coordinated. They are encoded through the activation kinetics of the pathway, a multitude of feedback loops, scaffold proteins, subcellular compartmentalisation, and crosstalk with other pathways. These regulatory motifs alone or in combination can generate a multitude of complex behaviour. Systems biology tries to decode this complexity through mathematical modelling and prediction in order to gain a deeper insight into the inner works of signalling networks.