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From protein networks to biological systems
Author(s) -
Uetz Peter,
Finley Russell L.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.02.001
Subject(s) - organism , systems biology , computational biology , computer science , biological network , protein–protein interaction , protein interaction networks , biological pathway , biological organism , information flow , process (computing) , biological system , biology , biological materials , biochemistry , genetics , gene expression , linguistics , philosophy , gene , operating system
A system‐level understanding of any biological process requires a map of the relationships among the various molecules involved. Technologies to detect and predict protein interactions have begun to produce very large maps of protein interactions, some including most of an organism's proteins. These maps can be used to study how proteins work together to form molecular machines and regulatory pathways. They also provide a framework for constructing predictive models of how information and energy flow through biological networks. In many respects, protein interaction maps are an entrée into systems biology.