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Statin‐inhibited endothelial permeability could be associated with its effect on PECAM‐1 in endothelial cells
Author(s) -
Wei Heming,
Fang Lu,
Song Jie,
Chatterjee Subroto
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2005.01.020
Subject(s) - lovastatin , statin , intracellular , microbiology and biotechnology , gtpase , small gtpase , endothelial stem cell , vascular permeability , chemistry , pharmacology , medicine , biology , signal transduction , biochemistry , in vitro , cholesterol
Conclusion: Statin‐reduced endothelial permeability could be attributed to altered intracellular distribution of PECAM‐1 in endothelial cells. We speculate that lovastatin regulates PECAM‐1 expression in HUVECs through the mevalonate‐GGPP pathway by inhibiting of Rho small GTPase.