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Expression of SERCA2a is not regulated by calcineurin or upon mechanical unloading in skeletal muscle regeneration
Author(s) -
Zádor Ernő,
Fenyvesi Rita,
Wuytack Frank
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.12.061
Subject(s) - calcineurin , gene isoform , soleus muscle , myosin , tenotomy , skeletal muscle , chemistry , microbiology and biotechnology , regeneration (biology) , endoplasmic reticulum , biology , biochemistry , endocrinology , medicine , anatomy , tendon , transplantation , gene
This study investigates to what extent the expression of the slow myosin heavy chain (MyHCI) isoform and the slow type sarcoplasmic reticulum Ca 2+ ATPase (SERCA2a) isoform are co‐regulated in fibers of regenerating skeletal soleus muscle. Both overexpression of cain, a calcineurin inhibitor, or partial tenotomy prevented the expression of MyHCI but left SERCA2a expression unaffected in fibers of regenerating soleus muscles. These data complement those from different experimental models and clearly show that the expression of MyHCI and SERCA2a – the major proteins mediating, respectively, the slow type of contraction and relaxation – are not coregulated in regenerating soleus muscle.