Premium
Activation of UCPs gene expression in skeletal muscle can be independent on both circulating fatty acids and food intake
Author(s) -
Busquets Sílvia,
Almendro Vanessa,
Barreiro Esther,
Figueras Maite,
Argilés Josep M.,
López-Soriano Francisco J.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.12.050
Subject(s) - ucp3 , pathophysiology , gene expression , endocrinology , medicine , skeletal muscle , wasting , biology , gene , wasting syndrome , uncoupling protein , genetics , obesity , brown adipose tissue
Implantation of a fast growing tumour to mice (Lewis lung carcinoma) resulted in a clear cachectic state characterized by a profound muscle wasting. This was accompanied by a significant increase in both UCP2 and UCP3 gene expression in skeletal muscle and heart. Interestingly, this increase in gene expression was not linked to a rise in circulating fatty acids or in a decrease in food intake, as previously reported in other pathophysiological states. These results question the concept that hyperlipaemia is the only factor controlling UCP gene expression in different pathophysiological conditions. In addition, the present work suggests that UCPs might participate in a counter‐regulatory mechanism to lower the production of ROS.