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Caenorhabditis elegans PMR1, a P‐type calcium ATPase, is important for calcium/manganese homeostasis and oxidative stress response
Author(s) -
Cho Jeong Hoon,
Ko Kyung Min,
Singaravelu Gunasekaran,
Ahnn Joohong
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.12.032
Subject(s) - caenorhabditis elegans , oxidative stress , microbiology and biotechnology , calcium , reactive oxygen species , homeostasis , biology , egta , oxidative phosphorylation , atpase , rna interference , golgi apparatus , chemistry , biochemistry , enzyme , gene , rna , organic chemistry , endoplasmic reticulum
The Caenorhabditis elegans PMR1, a P‐type Ca 2+ /Mn 2+ ATPase, is expressed in hypodermal seam cells, intestinal cells and spermatheca; localized in Golgi complex. Knock down of pmr‐1 as well as overexpression of truncated Caenorhabditis elegans PMR1, which mimics dominant mutations observed in human Hailey–Hailey disease, renders the worm highly sensitive to EGTA and Mn 2+ . Interestingly, pmr‐1 knock down not only causes animals to become resistant to oxidative stress but also suppresses high reactive oxygen species sensitivity of smf‐3 RNA‐mediated interference and daf‐16 worms. These findings suggest that C. elegans PMR1 has important roles in Ca 2+ and Mn 2+ homeostasis and oxidative stress response.