HCO    3    ‐     ‐independent rescue from apoptosis by stilbene derivatives in rat cardiomyocytes | Zendy

Tanabe Shigeru | Zendy; Wang Xiaoming | Zendy; Takahashi Nobuyuki | Zendy; Uramoto Hiromi | Zendy; Okada Yasunobu | Zendy

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HCO 3 ‐ ‐independent rescue from apoptosis by stilbene derivatives in rat cardiomyocytes

Author(s) -

Tanabe Shigeru,

Wang Xiaoming,

Takahashi Nobuyuki,

Uramoto Hiromi,

Okada Yasunobu

Publication year - 2005

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2004.12.020

Subject(s) - dna laddering , dids , staurosporine , apoptosis , chemistry , channel blocker , microbiology and biotechnology , programmed cell death , pharmacology , biochemistry , biology , signal transduction , protein kinase c , organic chemistry , membrane , dna fragmentation , calcium

Apoptosis of rat cardiomyocytes induced by staurosporine is prevented by a stilbene derivative (DIDS), which is a known blocker of bothCl ‐ / HCO 3 ‐exchangers and Cl − channels. To clarify its target, staurosporine‐induced activation of caspase‐3, DNA laddering and cell death were examined in cultured rat cardiomyocytes. Removal of ambientHCO 3 ‐, which minimizes the function ofCl ‐ / HCO 3 ‐exchangers, failed to affect the preventive effect of DIDS on apoptosis. A carboxylate analog Cl − channel blocker, which does not blockCl ‐ / HCO 3 ‐exchangers, also inhibited apoptotic events. Thus, rescue by DIDS of cardiomyocytes from apoptosis is mediated by blockage of Cl − channels.

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