Premium
Modes of remodeling in the cortical cytoskeleton of vascular endothelial cells
Author(s) -
Pesen Devrim,
Hoh Jan H.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.12.014
Subject(s) - cytoskeleton , microbiology and biotechnology , chemistry , biology , biophysics , cell , biochemistry
The cortical cytoskeleton of vascular endothelial cells plays an important role in responding to mechanical stimuli and controlling the distribution of cell surface proteins. Here, we have used atomic force microscopy to visualize the dynamics of cortical cytoskeleton in living bovine pulmonary artery endothelial cells. We demonstrate that the cortical cytoskeleton, organized as a complex polygonal mesh, is highly dynamic and shows two modes of remodeling: intact‐boundary‐mode where mesh element boundaries remain intact but move at ∼0.08 μm/min allowing the mesh element to change shape, and altered‐boundary‐mode where new mesh boundaries form and existing ones disappear.