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Baicalein 5,6,7‐trimethyl ether, a flavonoid derivative, stimulates fatty acid β‐oxidation in skin fibroblasts of X‐linked adrenoleukodystrophy
Author(s) -
Morita Masashi,
Takahashi Ikuko,
Kanai Mariko,
Okafuji Fumito,
Iwashima Makoto,
Hayashi Toshimitsu,
Watanabe Shiro,
Hamazaki Tomohito,
Shimozawa Nobuyuki,
Suzuki Yasuyuki,
Furuya Hirokazu,
Yamada Takeshi,
Imanaka Tsuneo
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.11.102
Subject(s) - adrenoleukodystrophy , baicalein , chemistry , flavonoid , peroxisome , fatty acid , ether , biochemistry , pharmacology , organic chemistry , antioxidant , medicine , gene
The purpose of the present study is to identify bioactive compounds with potential for X‐linked adrenoleukodystrophy (X‐ALD) pharmacological therapy. Various plant natural products including flavonoids were tested for their ability to ameliorate the abnormality of very long chain fatty acid (VLCFA) metabolism in cultured skin‐fibroblasts from X‐ALD patients. Of the compounds tested, baicalein 5,6,7‐trimethyl ether (baicalein‐tri‐Me) was found to significantly stimulate the VLCFA β‐oxidation activity. Furthermore, the incorporation of [1‐ 14 C]lignoceric acid into cholesteryl esters was markedly reduced towards the normal level and the VLCFA (C24:0 and C26:0) content was decreased. These results make baicalein‐tri‐Me a candidate for the therapeutic compound for X‐ALD.