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Identification and characterisation of a novel splice variant of the human CB1 receptor
Author(s) -
Ryberg Erik,
Vu Huy Khang,
Larsson Niklas,
Groblewski Thierry,
Hjorth Stephan,
Elebring Thomas,
Sjögren Sven,
Greasley Peter J.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.11.085
Subject(s) - splice , receptor , cannabinoid receptor , alternative splicing , biology , cloning (programming) , computational biology , identification (biology) , genetics , gene , cannabinoid , microbiology and biotechnology , messenger rna , agonist , botany , computer science , programming language
Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues.