Identification and characterisation of a novel splice variant of the human CB1 receptor | Zendy

Ryberg Erik | Zendy; Vu Huy Khang | Zendy; Larsson Niklas | Zendy; Groblewski Thierry | Zendy; Hjorth Stephan | Zendy; Elebring Thomas | Zendy; Sjögren Sven | Zendy; Greasley Peter J. | Zendy

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Identification and characterisation of a novel splice variant of the human CB1 receptor

Author(s) -

Ryberg Erik,

Vu Huy Khang,

Larsson Niklas,

Groblewski Thierry,

Hjorth Stephan,

Elebring Thomas,

Sjögren Sven,

Greasley Peter J.

Publication year - 2005

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2004.11.085

Subject(s) - splice , receptor , cannabinoid receptor , alternative splicing , biology , cloning (programming) , computational biology , identification (biology) , genetics , gene , cannabinoid , microbiology and biotechnology , messenger rna , agonist , botany , computer science , programming language

Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues.

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