Premium
Bilateral injection of isoproterenol into hippocampus induces Alzheimer‐like hyperphosphorylation of tau and spatial memory deficit in rat
Author(s) -
Sun Li,
Wang XiaoChuang,
Liu Shengyuan,
Wang Quan,
Wang JianZhi,
Bennecib Malika,
Gong Cheng-Xin,
Sengupta Amitabha,
Grundke-Iqbal Inge,
Iqbal Khalid
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.11.083
Subject(s) - hyperphosphorylation , hippocampus , kinase , cyclin dependent kinase 5 , neuroscience , phosphatase , protein kinase a , alzheimer's disease , tau protein , chemistry , activator (genetics) , microbiology and biotechnology , phosphorylation , biology , endocrinology , medicine , biochemistry , mitogen activated protein kinase kinase , receptor , disease
The abnormal hyperphosphorylation of tau protein is one of the hallmarks of Alzheimer disease and other tauopathies; as yet the exact role of various tau kinases in this pathology is not fully understood. Here, we show that injection of isoproterenol, an activator of cAMP‐dependent kinase (PKA), into rat hippocampus bilaterally results in the activation of PKA, calcium/calmodulin‐dependent kinase II and cyclin‐dependent kinase‐5, inhibition of protein phosphatase‐2A, hyperphosphorylation of tau at several Alzheimer‐like epitopes and a disturbance of spatial memory retention 48 h after the drug injection. These findings suggest the involvement of PKA and PKA‐mediated signaling pathway in the Alzheimer‐like tau hyperphosphorylation and memory impairment.