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Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line
Author(s) -
T'Sas France,
Brenner Carmen,
Mauen Sébastien,
Putmans Pascale,
Monté Didier,
Van Lint Carine,
Moser Muriel,
Baert Jean-Luc,
de Launoit Yvan
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.11.052
Subject(s) - transcription factor , microbiology and biotechnology , protein kinase c , signal transduction , line (geometry) , cell culture , chemistry , cancer research , biology , biochemistry , genetics , gene , mathematics , geometry
Erm, a member of the PEA3 group within the Ets family of transcription factors, is expressed in murine and human lymphocytes. Here, we show that in the human Molt4 lymphoblastic cell line, the erm gene expression is regulated by the conventional PKC (cPKC) pathway. To better characterize the molecular mechanism by which cPKC regulates Erm transcription in Molt4 cells, we tested proximal promoter deletions of the human gene, and identified a specific cPKC‐regulated region between positions −420 and −115 upstream of the first exon.