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The mammalian Mediator complex
Author(s) -
Conaway Joan Weliky,
Florens Laurence,
Sato Shigeo,
Tomomori-Sato Chieri,
Parmely Tari J.,
Yao Tingting,
Swanson Selene K.,
Banks Charles A.S.,
Washburn Michael P.,
Conaway Ronald C.
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.11.031
Subject(s) - mediator , rna polymerase ii , psychological repression , saccharomyces cerevisiae , multiprotein complex , regulator , protein subunit , transcription (linguistics) , biology , microbiology and biotechnology , transcription factor ii d , general transcription factor , genetics , computational biology , rna polymerase , rna , gene , promoter , gene expression , linguistics , philosophy
The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complex.