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Structure and dynamic properties of nucleosome core particles
Author(s) -
Chakravarthy Srinivas,
Park Young-Jun,
Chodaparambil Jayanth,
Edayathumangalam Rajeswari S.,
Luger Karolin
Publication year - 2005
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.11.030
Subject(s) - chromatin , nucleosome , histone , histone code , histone modifying enzymes , microbiology and biotechnology , chromatin remodeling , chromatosome , dna , histone h1 , biology , genetics , chemistry
It is now widely recognized that the packaging of genomic DNA, together with core histones, linker histones, and other functional proteins into chromatin profoundly influences nuclear processes such as transcription, replication, DNA repair, and recombination. Whereas earlier structural studies portrayed nucleosomes (the basic repeating unit of chromatin) as monolithic and static macromolecular assemblies, we now know that they are highly dynamic and capable of extensive crosstalk with the cellular machinery. Histone variants have evolved to locally alter chromatin structure, whereas histone chaperones and other cellular factors promote histone exchange and chromatin fluidity. Both of these phenomena likely facilitate interconversion between different chromatin states that show varying degrees of transcriptional activity.