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Identification and characterization of D8C, a novel domain present in liver‐specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy
Author(s) -
Yang Huirong,
Wu Chaoqun,
Zhao Shouyuan,
Guo Jinhu
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.10.092
Subject(s) - tamm–horsfall protein , cysteine , glycoprotein , biology , biochemistry , chemistry , genetics , microbiology and biotechnology , kidney , enzyme
Present work reported a novel domain – D8C (domain with conserved eight cysteines in liver‐specific ZP domain‐containing protein, glycoprotein 2 (GP‐2) and uromodulin (UMOD)), present in liver‐specific LZP, UMOD, GP‐2 and some uncharacterized proteins, most of which are membrane proteins, extracellular proteins or nuclear membrane proteins. D8C contains eight well‐conserved cysteine residues, which were predicted to form four pairs of disulfide bridges. D8C is composed mainly of β‐strands. Mutation in the D8C at Cys217 in human UMOD is associated with familial juvenile hyperuricaemic nephropathy, which might be due to the disruption of the disulfide bridge. Identification of D8C would further the understandings of related proteins.