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Regulating cell survival by controlling cellular energy production: novel functions for ancient signaling pathways?
Author(s) -
Kuznetsov Andrey V.,
Janakiraman Manickam,
Margreiter Raimund,
Troppmair Jakob
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.10.021
Subject(s) - microbiology and biotechnology , biogenesis , mitochondrial biogenesis , signal transduction , oxidative phosphorylation , biology , mitochondrion , glycolysis , cell growth , programmed cell death , cell survival , cell , homeostasis , apoptosis , metabolism , biochemistry , gene
Cell survival is maintained by growth factors and critically depends on sufficient energy supply. New evidence suggests that a rise in cellular energy production is not merely a homeostatic response to increased demand but subject to regulation by extrinsic factors. The mechanisms operating in this control are largely enigmatic. Work on transformed cells identified direct targeting of glycolytic enzymes by signaling proteins as one possibility. But mitochondrial oxidative phosphorylation and biogenesis may also be subject to regulation by growth and survival factors. Both, positive and negative regulators of cell survival impinge on the processes of cellular energy production to regulate growth and survival versus death.