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Potential anti‐atherogenic cell action of the naturally occurring 4‐ O ‐methyl derivative of gallic acid on Ang II‐treated macrophages
Author(s) -
Oliveira Maria V.Bizerra,
Badia Eric,
Carbonneau Marie-Annette,
Grimaldi Paul,
Fouret Gilles,
Lauret Celine,
Léger Claude L.
Publication year - 2004
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2004.10.015
Subject(s) - gallic acid , cd36 , chemistry , postprandial , polyphenol , foam cell , antioxidant , superoxide , cell , derivative (finance) , biochemistry , receptor , macrophage , endocrinology , in vitro , biology , enzyme , insulin , financial economics , economics
We have recently established that the blood concentrations of gallic acid (GA), a polyphenolic component naturally found in food, and its O ‐methyl derivatives are very low (practically ⩽1 μM) in physiological (postprandial) condition. Using acellular oxidant systems and macrophage‐differentiated promonocytes (MDPs) THP‐1, we show here that the direct and indirect (through depressing effect on the superoxide cell production) antioxidant properties of these components were not effective at these concentrations. In contrast, 4‐ O ‐methyl GA was the most efficient component to depress AT1R and CD36 mRNA expression in Ang II‐treated MDPs, suggesting a strong inhibition of Ang II‐triggered pro‐atherogenic mechanisms of foam cell formation.